MYBBP1A May activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity (HDAC activity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2. Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter. Has a role in rRNA biogenesis together with PWP1. Belongs to the MYBBP1A family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA replication; DNA-binding; Nucleolus; RNA-binding
Chromosomal Location of human Ortholog: 17p13.2
Cellular Component:  cytoplasm; intracellular membrane-bounded organelle; NLS-dependent protein nuclear import complex; nucleolus; nucleoplasm; nucleus
Molecular Function:  E-box binding; transcription corepressor activity; transcription factor binding
Biological Process:  cellular response to glucose starvation; circadian regulation of gene expression; intrinsic apoptotic signaling pathway by p53 class mediator; negative regulation of transcription, DNA-templated; positive regulation of anoikis; positive regulation of cell cycle arrest; positive regulation of gene expression, epigenetic; regulation of transcription, DNA-templated; respiratory electron transport chain; ribosome biogenesis
Reference #:  Q9BQG0 (UniProtKB)
Alt. Names/Synonyms: FLJ37886; MBB1A; MYB binding protein (P160) 1a; MYB binding protein 1a; Myb-binding protein 1A; MYBBP1A; P160; p53-activated protein-2; PAP2; Pol5
Gene Symbols: MYBBP1A
Molecular weight: 148,855 Da
Basal Isoelectric point: 9.34  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein