VIRMA Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites. Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon correlating with alternative polyadenylation (APA). Belongs to the vir family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA processing; Spliceosome
Chromosomal Location of human Ortholog: 8q22.1
Cellular Component:  cytosol; nuclear body; nuclear speck; nucleoplasm; RNA N6-methyladenosine methyltransferase complex
Molecular Function:  protein binding
Biological Process:  mRNA alternative polyadenylation; mRNA methylation; mRNA processing; multicellular organism development; RNA splicing
Reference #:  Q69YN4 (UniProtKB)
Alt. Names/Synonyms: DKFZp434I116; DKFZp781B2117; fSAP121; functional spliceosome-associated protein 121; KIAA1429; MGC138493; MGC141940; MSTP054; Protein virilizer homolog; VIR; vir like m6A methyltransferase associated; virilizer homolog; VIRMA
Gene Symbols: VIRMA
Molecular weight: 202,025 Da
Basal Isoelectric point: 4.9  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein