JMJD1A Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1. Belongs to the JHDM2 histone demethylase family. Note: This description may include information from UniProtKB.
Protein type: Demethylase; EC 1.14.11.-; Nuclear receptor co-regulator; Oxidoreductase
Chromosomal Location of Human Ortholog: 2p11.2
Cellular Component:  cytoplasm; nucleoplasm; nucleus
Molecular Function:  androgen receptor binding; dioxygenase activity; DNA-binding transcription factor activity; histone demethylase activity (H3-K9 specific); iron ion binding; protein binding; RNA polymerase II core promoter sequence-specific DNA binding
Biological Process:  androgen receptor signaling pathway; cellular response to leukemia inhibitory factor; formaldehyde biosynthetic process; histone H3-K9 demethylation; histone H3-K9 dimethylation; hormone-mediated signaling pathway; negative regulation of histone H3-K9 methylation; oxidation-reduction process; positive regulation of cold-induced thermogenesis; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of stem cell differentiation; regulation of stem cell population maintenance; spermatid nucleus elongation
Reference #:  Q9Y4C1 (UniProtKB)
Alt. Names/Synonyms: DKFZp686A24246; DKFZp686P07111; JHDM2A; JHMD2A; JmjC domain-containing histone demethylation protein 2A; JMJD1; JMJD1A; jumonji C domain-containing histone demethylase 2A; jumonji domain containing 1; jumonji domain containing 1A; Jumonji domain-containing protein 1A; KDM3A; KIAA0742; lysine (K)-specific demethylase 3A; Lysine-specific demethylase 3A; testis-specific protein A; TSGA
Gene Symbols: KDM3A
Molecular weight: 147,341 Da
Basal Isoelectric point: 8.4  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
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Protein Structure Not Found.

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