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NBA1
Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination. Belongs to the BABAM1 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA repair, damage |
| Chromosomal Location of human Ortholog: 19p13.11 |
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Cellular Component:
BRCA1-A complex; BRISC complex; cytoplasm; cytosol; nuclear body; nucleoplasm; nucleus
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Molecular Function:
protein binding
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Biological Process:
cell division; chromatin organization; double-strand break repair; hematopoietic stem cell proliferation; histone H2A K63-linked deubiquitination; mitotic G2 DNA damage checkpoint signaling; mitotic G2/M transition checkpoint; positive regulation of DNA repair; protein K63-linked deubiquitination; regulation of DNA repair; response to ionizing radiation
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Reference #:
Q9NWV8
(UniProtKB)
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Alt. Names/Synonyms: BABA1; BABAM1; BRCA1-A complex subunit MERIT40; BRISC and BRCA1 A complex member 1; BRISC and BRCA1-A complex member 1; C19orf62; chromosome 19 open reading frame 62; FLJ20571; HSPC142; mediator of Rap80 interactions and targeting 40 kDa; Mediator of RAP80 interactions and targeting subunit of 40 kDa; MERIT40; MRI40; NBA1; New component of the BRCA1-A complex; new component of the BRCAA1 A complex
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Gene Symbols: BABAM1
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Molecular weight:
36,560 Da
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Basal Isoelectric point:
4.6
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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