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NBA1
a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The VWFA-like region is similar to the VWFA domain. Its presence reveals similarities between the structure of the 19S proteasome and the BRCA1-A complexes. Two alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA repair, damage |
| Chromosomal Location of Human Ortholog: 19p13.11 |
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Cellular Component:
BRCA1-A complex; BRISC complex; cytoplasm; cytosol; nuclear body; nucleoplasm; nucleus
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Molecular Function:
protein binding
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Biological Process:
cell cycle; cell division; chromatin organization; double-strand break repair; double-strand break repair via nonhomologous end joining; positive regulation of DNA repair; protein deubiquitination; protein K63-linked deubiquitination; response to ionizing radiation; signal transduction involved in G2 DNA damage checkpoint
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Reference #:
Q9NWV8
(UniProtKB)
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Alt. Names/Synonyms: BABAM1; BRCA1-A complex subunit MERIT40; BRISC and BRCA1-A complex member 1; C19orf62; chromosome 19 open reading frame 62; FLJ20571; HSPC142; mediator of Rap80 interactions and targeting 40 kDa; Mediator of RAP80 interactions and targeting subunit of 40 kDa; MERIT40; MRI40; NBA1; New component of the BRCA1-A complex; new component of the BRCAA1 A complex
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Gene Symbols: BABAM1
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Molecular weight:
36,560 Da
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Basal Isoelectric point:
4.6
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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