HIP14 Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. May play a role in Mg(2+) transport. Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily. Expressed in all brain regions. Expression is highest in the cortex, cerebellum, occipital lobe and caudate and lowest in the spinal cord. Expression is also seen in testis, pancreas, heart and kidney. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Membrane protein, integral; Membrane protein, multi-pass; Transferase; Tumor suppressor
Chromosomal Location of Human Ortholog: 12q21.2
Cellular Component:  aggresome; cell junction; cytoplasmic vesicle membrane; Golgi apparatus; Golgi membrane; Golgi-associated vesicle membrane; integral component of membrane; intracellular membrane-bounded organelle; presynaptic membrane
Molecular Function:  identical protein binding; magnesium ion transmembrane transporter activity; palmitoyltransferase activity; protein binding; protein-cysteine S-palmitoyltransferase activity
Biological Process:  lipoprotein transport; magnesium ion transmembrane transport; protein palmitoylation
Reference #:  Q8IUH5 (UniProtKB)
Alt. Names/Synonyms: DHHC-17; HIP-14; HIP-3; HIP14; HIP3; HSPC294; huntingtin interacting protein 14; huntingtin interacting protein 3; Huntingtin interacting protein H; Huntingtin yeast partner H; Huntingtin-interacting protein 14; Huntingtin-interacting protein 3; Huntingtin-interacting protein H; HYPH; KIAA0946; Palmitoyltransferase ZDHHC17; Putative MAPK-activating protein PM11; Putative NF-kappa-B-activating protein 205; ZDH17; ZDHHC17; Zinc finger DHHC domain-containing protein 17; zinc finger, DHHC domain containing 17; zinc finger, DHHC-type containing 17
Gene Symbols: ZDHHC17
Molecular weight: 72,640 Da
Basal Isoelectric point: 7.29  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein