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CTDP1
Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation. Ubiquitously expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.3.16; Motility/polarity/chemotaxis; Protein phosphatase, Ser/Thr (non-receptor); Transcription initiation complex |
| Chromosomal Location of human Ortholog: 18q23 |
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Cellular Component:
centrosome; cytoplasm; intracellular membrane-bounded organelle; midbody; nucleoplasm; nucleus; protein-containing complex; spindle; spindle midzone; spindle pole
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Molecular Function:
myosin phosphatase activity; phosphoprotein phosphatase activity; protein binding; RNA polymerase II CTD heptapeptide repeat phosphatase activity; Tat protein binding; TFIIF-class transcription factor complex binding
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Biological Process:
cell division; exit from mitosis; negative regulation of cell growth involved in cardiac muscle cell development; positive regulation by host of viral transcription; protein dephosphorylation; regulation of transcription by RNA polymerase II; transcription elongation by RNA polymerase II
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Disease: Congenital Cataracts, Facial Dysmorphism, And Neuropathy
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Reference #:
Q9Y5B0
(UniProtKB)
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Alt. Names/Synonyms: CCFDN; CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1; CTD of POLR2A, phosphatase of, subunit 1; CTD phosphatase subunit 1; CTDP1; FCP1; RNA polymerase II subunit A C-terminal domain phosphatase; serine phosphatase FCP1a; TFIIF-associating CTD phosphatase; TFIIF-associating CTD phosphatase 1; transcription factor IIF-associating CTD phosphatase 1
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Gene Symbols: CTDP1
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Molecular weight:
104,399 Da
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Basal Isoelectric point:
5.17
Predict pI for various phosphorylation states
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