EXO1 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch- containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis. Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.-.-; Hydrolase
Chromosomal Location of Human Ortholog: 1q43
Cellular Component:  nuclear body; nucleoplasm; nucleus; plasma membrane
Molecular Function:  5'-3' exodeoxyribonuclease activity; 5'-3' exonuclease activity; chromatin binding; DNA binding; double-stranded DNA 5'-3' exodeoxyribonuclease activity; exonuclease activity; flap endonuclease activity; metal ion binding; protein binding; RNA-DNA hybrid ribonuclease activity; single-stranded DNA 5'-3' exodeoxyribonuclease activity
Biological Process:  DNA recombination; DNA repair; DNA replication; humoral immune response mediated by circulating immunoglobulin; isotype switching; meiotic cell cycle; mismatch repair; regulation of signal transduction by p53 class mediator; RNA phosphodiester bond hydrolysis, endonucleolytic; somatic hypermutation of immunoglobulin genes; t-circle formation
Reference #:  Q9UQ84 (UniProtKB)
Alt. Names/Synonyms: EXO1; EXOI; Exonuclease 1; Exonuclease I; HEX1; hExo1; hExoI; rad2 nuclease family member, homolog of S. cerevisiae exonuclease 1
Gene Symbols: EXO1
Molecular weight: 94,103 Da
Basal Isoelectric point: 8.59  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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