EXO1
5'- Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily. Highly expressed in bone marrow, testis and thymus. Expressed at lower levels in colon, lymph nodes, ovary, placenta, prostate, small intestine, spleen and stomach. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: EC 3.1.-.-; Hydrolase |
Chromosomal Location of human Ortholog: 1q43 |
Cellular Component:
nuclear body; nucleoplasm; nucleus; plasma membrane
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Molecular Function:
5'-3' DNA exonuclease activity; 5'-3' exonuclease activity; 5'-flap endonuclease activity; chromatin binding; DNA binding; double-stranded DNA 5'-3' exodeoxyribonuclease activity; exonuclease activity; flap endonuclease activity; metal ion binding; protein binding; RNA-DNA hybrid ribonuclease activity; single-stranded DNA 5'-3' DNA exonuclease activity
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Biological Process:
DNA recombination; DNA repair; humoral immune response mediated by circulating immunoglobulin; isotype switching; meiotic cell cycle; mismatch repair; somatic hypermutation of immunoglobulin genes; t-circle formation
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Reference #:
Q9UQ84
(UniProtKB)
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Alt. Names/Synonyms: EXO1; EXOI; Exonuclease 1; Exonuclease I; HEX1; hExo1; hExoI; rad2 nuclease family member, homolog of S. cerevisiae exonuclease 1
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Gene Symbols: EXO1
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Molecular weight:
94,103 Da
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Basal Isoelectric point:
8.59
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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