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LRWD1
Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability. Belongs to the LRWD1 family. Testis-specific. Drastically down-regulated in testis from patients with Sertoli cell-only syndrome (SCOS). Note: This description may include information from UniProtKB.
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| Protein type: DNA replication; DNA-binding; Histone-binding |
| Chromosomal Location of human Ortholog: 7q22.1 |
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Cellular Component:
chromosome, telomeric region; cytoplasm; intracellular membrane-bounded organelle; kinetochore; microtubule organizing center; nuclear origin of replication recognition complex; nucleolus; nucleoplasm; nucleus; pericentric heterochromatin
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Molecular Function:
chromatin binding; methyl-CpG binding; methylated histone binding; protein binding
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Biological Process:
chromatin organization; DNA replication initiation; establishment of protein localization to chromatin
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Reference #:
Q9UFC0
(UniProtKB)
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Alt. Names/Synonyms: CENP-33; Centromere protein 33; DKFZp434K1815; leucine rich repeats and WD repeat domain containing 1; Leucine-rich repeat and WD repeat-containing protein 1; leucine-rich repeats and WD repeat domain containing 1; LRWD1; ORC-associated protein; ORCA; Origin recognition complex-associated protein; testicular tissue protein Li 4
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Gene Symbols: LRWD1
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Molecular weight:
70,861 Da
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Basal Isoelectric point:
6.88
Predict pI for various phosphorylation states
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