LRWD1 Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability. Belongs to the LRWD1 family. Testis-specific. Drastically down-regulated in testis from patients with Sertoli cell-only syndrome (SCOS). Note: This description may include information from UniProtKB.
Protein type: DNA replication; DNA-binding; Histone-binding
Chromosomal Location of Human Ortholog: 7q22.1
Cellular Component:  condensed chromosome kinetochore; cytoplasm; intracellular membrane-bounded organelle; kinetochore; microtubule organizing center; nuclear origin of replication recognition complex; nucleolus; nucleus; pericentric heterochromatin; telomeric heterochromatin
Molecular Function:  chromatin binding; methyl-CpG binding; methylated histone binding; protein binding
Biological Process:  chromatin organization; DNA replication initiation; establishment of protein localization to chromatin
Reference #:  Q9UFC0 (UniProtKB)
Alt. Names/Synonyms: DKFZp434K1815; Leucine-rich repeat and WD repeat-containing protein 1; leucine-rich repeats and WD repeat domain containing 1; LRWD1
Gene Symbols: LRWD1
Molecular weight: 70,861 Da
Basal Isoelectric point: 6.88  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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