CTF18 Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates DNA polymerase POLH. Belongs to the activator 1 small subunits family. CTF18 subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA replication
Chromosomal Location of human Ortholog: 16p13.3
Cellular Component:  Ctf18 RFC-like complex; cytosol; nucleoplasm; nucleus
Molecular Function:  ATP binding; ATP hydrolysis activity; DNA binding; DNA clamp loader activity; protein binding; single-stranded DNA helicase activity
Biological Process:  cell cycle; DNA duplex unwinding; DNA replication; positive regulation of DNA-directed DNA polymerase activity
Reference #:  Q8WVB6 (UniProtKB)
Alt. Names/Synonyms: C16orf41; C321D2.2; C321D2.3; C321D2.4; CHL12; chromosome transmission fidelity factor 18; Chromosome transmission fidelity protein 18 homolog; CHTF18; CTF18; CTF18, chromosome transmission fidelity factor 18 homolog; CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae); hCTF18; homolog of yeast CHL12; RUVBL; some homology with holliday junction DNA helicase RUVB like
Gene Symbols: CHTF18
Molecular weight: 107,383 Da
Basal Isoelectric point: 6.78  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein