ARID4B Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor. Highly expressed in the testis and in breast, lung, colon, pancreatic and ovarian cancers. Expressed at low levels in the thymus, prostate and ovary. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of human Ortholog: 1q42.3
Cellular Component:  cytoplasm; nucleoplasm
Molecular Function:  DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding
Biological Process:  establishment of Sertoli cell barrier; histone H3-K9 trimethylation; histone H4-K20 trimethylation; positive regulation of transcription by RNA polymerase II; regulation of gene expression by genetic imprinting; spermatogenesis
Reference #:  Q4LE39 (UniProtKB)
Alt. Names/Synonyms: 180 kDa Sin3-associated polypeptide; ARI4B; ARID domain-containing protein 4B; ARID4B; AT rich interactive domain 4B (RBP1-like); AT-rich interaction domain 4B; AT-rich interactive domain-containing protein 4B; BCAA; BRCAA1; breast cancer-associated antigen 1; Breast cancer-associated antigen BRCAA1; breast carcinoma-associated antigen; DKFZp313M2420; Histone deacetylase complex subunit SAP180; MGC163290; Rb-binding protein homolog; RBBP1L1; RBP1-like protein; RBP1L1; retinoblastoma binding protein 1-like 1; Retinoblastoma-binding protein 1-like 1; SAP180; Sin3-associated polypeptide p180; SIN3A-associated protein 180
Gene Symbols: ARID4B
Molecular weight: 147,809 Da
Basal Isoelectric point: 5.04  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein