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APRIN
Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells. Belongs to the PDS5 family. Widely expressed. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell development/differentiation; DNA-binding |
| Chromosomal Location of Human Ortholog: 13q13.1 |
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Cellular Component:
chromatin; chromosome; chromosome, centromeric region; cytosol; nucleoplasm; nucleus
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Molecular Function:
DNA binding; protein binding
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Biological Process:
cell division; cell proliferation; lens development in camera-type eye; mitotic sister chromatid cohesion; negative regulation of cell proliferation; neuroblast migration; regulation of cell proliferation
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Reference #:
Q9NTI5
(UniProtKB)
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Alt. Names/Synonyms: Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein LOC641515; androgen induced inhibitor of proliferation; Androgen-induced proliferation inhibitor; androgen-induced prostate proliferative shutoff associated protein; Androgen-induced prostate proliferative shutoff-associated protein AS3; androgen-induced shutoff 3; APRIN; AS3; CG008; FLJ23236; KIAA0979; PDS5 cohesin associated factor B; PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae); PDS5B; RP1-267P19.1; Sister chromatid cohesion protein PDS5 homolog B
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Gene Symbols: PDS5B
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Molecular weight:
164,667 Da
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Basal Isoelectric point:
8.67
Predict pI for various phosphorylation states
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