|
HNMT iso2
Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine. Belongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Amino Acid Metabolism - histidine; EC 2.1.1.8; Methyltransferase |
| Chromosomal Location of Human Ortholog: 2q22.1 |
|
Cellular Component:
cytoplasm; cytosol
|
|
Molecular Function:
histamine N-methyltransferase activity
|
|
Biological Process:
histamine catabolic process; histidine catabolic process; hyperosmotic response; methylation; respiratory gaseous exchange; response to amine; response to cocaine; response to glucocorticoid; response to immobilization stress; response to interleukin-1; response to tumor cell
|
|
Disease: Asthma, Susceptibility To; Mental Retardation, Autosomal Recessive 51
|
|
Reference #:
P50135-2
(UniProtKB)
|
|
Alt. Names/Synonyms: Histamine N-methyltransferase; Histamine N-methyltransferase short variant 1; Histamine N-methyltransferase short variant 2; Histamine N-methyltransferase, isoform CRA_a; HMT; HNMT; HNMT iso2; HNMT-S1; HNMT-S2; MRT51
|
|
Gene Symbols: HNMT
|
|
Molecular weight:
14,207 Da
|
|
Basal Isoelectric point:
9.59
Predict pI for various phosphorylation states
|
