HNMT iso2 Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine. Belongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - histidine; EC 2.1.1.8; Methyltransferase
Chromosomal Location of Human Ortholog: 2q22.1
Cellular Component:  cytoplasm; cytosol
Molecular Function:  histamine N-methyltransferase activity
Biological Process:  histamine catabolic process; histidine catabolic process; hyperosmotic response; methylation; respiratory gaseous exchange; response to amine; response to cocaine; response to glucocorticoid; response to immobilization stress; response to interleukin-1; response to tumor cell
Disease: Asthma, Susceptibility To; Mental Retardation, Autosomal Recessive 51
Reference #:  P50135-2 (UniProtKB)
Alt. Names/Synonyms: Histamine N-methyltransferase; Histamine N-methyltransferase short variant 1; Histamine N-methyltransferase short variant 2; Histamine N-methyltransferase, isoform CRA_a; HMT; HNMT; HNMT iso2; HNMT-S1; HNMT-S2; MRT51
Gene Symbols: HNMT
Molecular weight: 14,207 Da
Basal Isoelectric point: 9.59  Predict pI for various phosphorylation states
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HNMT iso2

Protein Structure Not Found.


Cross-references to other databases:  cBioPortal  |  Wikipedia  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene