PI4K2A Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily. Widely expressed. Highest expression is observed in kidney, brain, heart, skeletal muscle, and placenta and lowest expression is observed in colon, thymus, and small intestine. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, lipid; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 10q24.2
Cellular Component:  cell junction; cytoplasmic vesicle; cytosol; dendrite; early endosome membrane; endosome; growing cell tip; host cell presynaptic membrane; integral component of plasma membrane; intrinsic component of membrane; membrane raft; mitochondrion; neuron projection; neuronal cell body; perikaryon; presynaptic membrane; synaptic vesicle membrane
Molecular Function:  1-phosphatidylinositol 4-kinase activity; AP-3 adaptor complex binding; ATP binding; magnesium ion binding; protein binding
Biological Process:  basophil degranulation; phosphatidylinositol biosynthetic process; phosphatidylinositol phosphorylation
Reference #:  Q9BTU6 (UniProtKB)
Alt. Names/Synonyms: DKFZp761G1923; P4K2A; phosphatidylinositol 4-kinase type 2 alpha; Phosphatidylinositol 4-kinase type 2-alpha; phosphatidylinositol 4-kinase type II (PI4KII); Phosphatidylinositol 4-kinase type II-alpha; PI4K2A; PI4KII; PIK42A; RP11-548K23.6
Gene Symbols: PI4K2A
Molecular weight: 54,022 Da
Basal Isoelectric point: 8.51  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene