UACA
Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1. Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury. May be involved in multiple neurite formation. Highly expressed in skeletal muscle, heart, kidney and pancreas. Expressed in choroid, retina and epidermal melanocytes. Expressed in eye muscles and thyroid follicular cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Apoptosis |
Chromosomal Location of human Ortholog: 15q23 |
Cellular Component:
cytoskeleton; cytosol; extracellular region; nucleoplasm; nucleus
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Molecular Function:
actin binding; protein binding
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Biological Process:
negative regulation of NIK/NF-kappaB signaling; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
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Reference #:
Q9BZF9
(UniProtKB)
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Alt. Names/Synonyms: FLJ10128; KIAA1561; MGC141967; MGC141969; nuclear membrane binding protein; NUCLING; UACA; uveal autoantigen with coiled coil domains and ankyrin repeats; Uveal autoantigen with coiled-coil domains and ankyrin repeats
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Gene Symbols: UACA
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Molecular weight:
162,505 Da
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Basal Isoelectric point:
6.6
Predict pI for various phosphorylation states
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