FBX38 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of PDCD1/PD-1, thereby regulating T-cells-mediated immunity. Required for anti-tumor activity of T-cells by promoting the degradation of PDCD1/PD-1; the PDCD1-mediated inhibitory pathway being exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival. May indirectly stimulate the activity of transcription factor KLF7, a regulator of neuronal differentiation, without promoting KLF7 ubiquitination. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 5q32
Cellular Component:  cytoplasm; cytosol; nucleus; SCF ubiquitin ligase complex
Molecular Function:  protein binding
Biological Process:  adaptive immune response; positive regulation of neuron projection development; positive regulation of T cell mediated immune response to tumor cell; protein K48-linked ubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Disease: Neuronopathy, Distal Hereditary Motor, Type Iid
Reference #:  Q6PIJ6 (UniProtKB)
Alt. Names/Synonyms: F-box only protein 38; F-box protein 38; Fbx38; FBXO38; HMN2D; Modulator of KLF7 activity homolog; MoKA; SP329
Gene Symbols: FBXO38
Molecular weight: 133,944 Da
Basal Isoelectric point: 5.92  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein