FBX38 Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. May coactivate KLF7, but does not seem to promote KLF7 ubiquitination. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 5q32
Cellular Component:  cytoplasm; cytosol; nucleus; SCF ubiquitin ligase complex
Molecular Function:  protein binding
Biological Process:  adaptive immune response; positive regulation of neuron projection development; positive regulation of T cell mediated immune response to tumor cell; protein K48-linked ubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Disease: Neuronopathy, Distal Hereditary Motor, Type Iid
Reference #:  Q6PIJ6 (UniProtKB)
Alt. Names/Synonyms: F-box only protein 38; F-box protein 38; Fbx38; FBXO38; Modulator of KLF7 activity homolog; MoKA; SP329
Gene Symbols: FBXO38
Molecular weight: 133,944 Da
Basal Isoelectric point: 5.92  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein