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PNN
Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Component of the PSAP complex which binds RNA in a sequence-independent manner and is proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma. Belongs to the pinin family. Expressed in placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, epidermis, esophagus, brain and smooth and skeletal muscle. Expressed strongly in melanoma metastasis lesions and advanced primary tumors. Note: This description may include information from UniProtKB.
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| Protein type: RNA splicing; RNA-binding; Spliceosome; Transcription, coactivator/corepressor; Tumor suppressor |
| Chromosomal Location of human Ortholog: 14q21.1 |
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Cellular Component:
catalytic step 2 spliceosome; cell-cell junction; desmosome; intermediate filament; nuclear speck; nucleoplasm; plasma membrane
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Molecular Function:
DNA binding; protein binding; structural molecule activity
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Biological Process:
cell adhesion; mRNA splicing, via spliceosome
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Reference #:
Q9H307
(UniProtKB)
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Alt. Names/Synonyms: 140 kDa nuclear and cell adhesion-related phosphoprotein; Desmosome-associated protein; Domain-rich serine protein; DRS; DRS protein; DRSP; Melanoma metastasis clone A protein; MEMA; neutrophil protein; Nuclear protein SDK3; Pinin; pinin, desmosome associated protein; PNN; SDK3; SR-like protein
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Gene Symbols: PNN
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Molecular weight:
81,628 Da
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Basal Isoelectric point:
6.71
Predict pI for various phosphorylation states
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| Select Structure to View Below |
PNN
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