PDGFRB Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Oncoprotein; PDGFR family; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 5q32
Cellular Component:  apical plasma membrane; cell surface; cytoplasm; cytoplasmic vesicle; Golgi apparatus; intracellular membrane-bounded organelle; intrinsic component of plasma membrane; lysosomal lumen; membrane; nucleus; plasma membrane
Molecular Function:  ATP binding; enzyme binding; phosphatidylinositol 3-kinase binding; platelet activating factor receptor activity; platelet-derived growth factor beta-receptor activity; platelet-derived growth factor binding; platelet-derived growth factor receptor binding; protein binding; protein kinase binding; protein tyrosine kinase activity; signaling receptor binding; vascular endothelial growth factor binding
Biological Process:  aging; aorta morphogenesis; cardiac myofibril assembly; cell chemotaxis; cell migration; cell migration involved in coronary angiogenesis; cell migration involved in vasculogenesis; cellular response to platelet-derived growth factor stimulus; G protein-coupled receptor signaling pathway; glycosaminoglycan biosynthetic process; inner ear development; lung growth; male gonad development; MAPK cascade; metanephric comma-shaped body morphogenesis; metanephric glomerular capillary formation; metanephric glomerular mesangial cell proliferation involved in metanephros development; metanephric mesenchymal cell migration; metanephric mesenchyme development; metanephric S-shaped body morphogenesis; negative regulation of apoptotic process; peptidyl-tyrosine phosphorylation; phosphatidylinositol metabolic process; phosphatidylinositol-mediated signaling; platelet-derived growth factor receptor signaling pathway; platelet-derived growth factor receptor-beta signaling pathway; positive regulation of apoptotic process; positive regulation of calcium ion import; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway; positive regulation of chemotaxis; positive regulation of collagen biosynthetic process; positive regulation of DNA biosynthetic process; positive regulation of ERK1 and ERK2 cascade; positive regulation of fibroblast proliferation; positive regulation of hepatic stellate cell activation; positive regulation of MAP kinase activity; positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway; positive regulation of mitotic nuclear division; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of phospholipase C activity; positive regulation of phosphoprotein phosphatase activity; positive regulation of protein kinase B signaling; positive regulation of reactive oxygen species metabolic process; positive regulation of Rho protein signal transduction; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; protein autophosphorylation; regulation of actin cytoskeleton organization; response to estradiol; response to estrogen; response to fluid shear stress; response to hydrogen peroxide; response to hyperoxia; response to retinoic acid; retina vasculature development in camera-type eye; signal transduction; smooth muscle cell chemotaxis; wound healing
Disease: Basal Ganglia Calcification, Idiopathic, 1; Basal Ganglia Calcification, Idiopathic, 4; Kosaki Overgrowth Syndrome; Myeloproliferative Disorder, Chronic, With Eosinophilia; Myofibromatosis, Infantile, 1; Premature Aging Syndrome, Penttinen Type
Reference #:  P09619 (UniProtKB)
Alt. Names/Synonyms: Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; CD140B; JTK12; PDGF-R-beta; PDGFR; PDGFR1; PDGFRB; PGFRB; Platelet-derived growth factor receptor beta; platelet-derived growth factor receptor, beta polypeptide
Gene Symbols: PDGFRB
Molecular weight: 123,968 Da
Basal Isoelectric point: 4.88  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PDGFRB

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