PAK1IP1 Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which have been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. Note: This description may include information from UniProtKB.
Protein type: Inhibitor; Nucleolus
Chromosomal Location of Human Ortholog: 6p24.2
Cellular Component:  nucleolus
Molecular Function:  protein binding
Biological Process:  cell proliferation; negative regulation of signal transduction; regulation of signal transduction by p53 class mediator; ribosomal large subunit biogenesis; roof of mouth development
Reference #:  Q9NWT1 (UniProtKB)
Alt. Names/Synonyms: bA421M1.5; FLJ20624; hPIP1; MAK11; p21-activated protein kinase-interacting protein 1; PAK/PLC-interacting protein 1; PAK1 interacting protein 1; PAK1-interacting protein 1; PAK1IP1; PIP1; PK1IP; RP11-421M1.5; WD repeat-containing protein 84; WDR84
Gene Symbols: PAK1IP1
Molecular weight: 43,964 Da
Basal Isoelectric point: 9.07  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene