HBXAP Required for assembly of regular nucleosome arrays by the RSF chromatin-remodeling complex. Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain. Ubiquitously expressed. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of human Ortholog: 11q14.1
Cellular Component:  nucleoplasm; nucleus; RSF complex
Molecular Function:  histone binding; metal ion binding; protein binding
Biological Process:  CENP-A containing nucleosome assembly; chromatin remodeling; DNA-templated transcription, initiation; histone acetylation; negative regulation of DNA binding; negative regulation of transcription, DNA-templated; nucleosome assembly; nucleosome positioning; positive regulation of transcription, DNA-templated; positive regulation of viral transcription
Reference #:  Q96T23 (UniProtKB)
Alt. Names/Synonyms: HBV pX associated protein-8; HBV pX-associated protein 8; HBXAP; hepatitis B virus x associated protein; Hepatitis B virus X-associated protein; p325; p325 subunit of RSF chromatin-remodeling complex; Remodeling and spacing factor 1; Rsf-1; RSF1; XAP8
Gene Symbols: RSF1
Molecular weight: 163,821 Da
Basal Isoelectric point: 4.94  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene