RHBDF1 Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration. Belongs to the peptidase S54 family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component:  endoplasmic reticulum membrane; Golgi membrane; integral component of membrane
Molecular Function:  growth factor binding; protein binding
Biological Process:  cell migration; cell proliferation; negative regulation of protein secretion; protein transport; proteolysis; regulation of epidermal growth factor receptor signaling pathway; regulation of proteasomal protein catabolic process; regulation of protein secretion
Reference #:  Q96CC6 (UniProtKB)
Alt. Names/Synonyms: C16orf8; Dist1; EGFR-RS; epidermal growth factor receptor, related sequence; FLJ2235; FLJ22357; gene-89; gene-90; hDist1; Inactive rhomboid protein 1; p100hRho; RHBDF1; RHDF1; Rhomboid 5 homolog 1; rhomboid 5 homolog 1 (Drosophila); rhomboid family 1; Rhomboid family member 1
Gene Symbols: RHBDF1
Molecular weight: 97,401 Da
Basal Isoelectric point: 8.8  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB