Pur-beta Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs. Belongs to the PUR DNA-binding protein family. Expressed in myocardium of heart failure patients. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; RNA-binding
Chromosomal Location of human Ortholog: 7p13
Cellular Component:  nucleoplasm; nucleus
Molecular Function:  DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; mRNA binding; protein binding; purine-rich negative regulatory element binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; single-stranded DNA binding; SMAD binding
Biological Process:  negative regulation of transcription by RNA polymerase II; regulation of myeloid cell differentiation; regulation of transcription by RNA polymerase II
Reference #:  Q96QR8 (UniProtKB)
Alt. Names/Synonyms: MGC126784; MGC126786; Pur-beta; PURB; PURBETA; purine rich element binding protein B; purine-rich element binding protein B; Purine-rich element-binding protein B; Transcriptional activator protein Pur-beta
Gene Symbols: PURB
Molecular weight: 33,241 Da
Basal Isoelectric point: 5.35  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein