HEXIM2 a transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. Component of the 7SK snRNP complex containing at least the P-TEFb complex (CDK9/CCNT1, HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs). Up-regulated by HMBA (hexamethylene bisacetamide) (at protein level). A coiled-coil domain mediates oligomerization. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 17q21.31
Cellular Component:  cytoplasm; cytosol; nuclear speck; nucleoplasm; nucleus
Molecular Function:  7SK snRNA binding; cyclin-dependent protein serine/threonine kinase inhibitor activity; identical protein binding; protein binding; snRNA binding
Biological Process:  negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated
Reference #:  Q96MH2 (UniProtKB)
Alt. Names/Synonyms: FLJ32384; Hexamethylene bis-acetamide-inducible protein 2; hexamethylene-bis-acetamide-inducible transcript 2; hexamthylene bis-acetamide inducible 2; HEXI2; HEXIM2; L3; MAQ1 paralog; Protein HEXIM2
Gene Symbols: HEXIM2
Molecular weight: 32,419 Da
Basal Isoelectric point: 6.13  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene