MAGE-G1 Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest. Ubiquitous. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 15q13.1
Cellular Component:  chromosome, telomeric region; cytoplasm; nucleoplasm; Smc5-Smc6 complex
Molecular Function:  protein binding; protein dimerization activity
Biological Process:  cellular response to hydroxyurea; cellular response to radiation; cellular response to UV; DNA recombination; DNA repair; positive regulation of protein ubiquitination; regulation of growth
Disease: Lung Disease, Immunodeficiency, And Chromosome Breakage Syndrome
Reference #:  Q96MG7 (UniProtKB)
Alt. Names/Synonyms: HCA4; Hepatocellular carcinoma-associated protein 4; hepatocellular carcinoma-associated protein HCA4; MAGE-G1 antigen; MAGEG1; MAGEL3; MAGG1; melanoma antigen, family G, 1; Melanoma-associated antigen G1; NDNL2; necdin-like 2; necdin-like gene 2; Necdin-like protein 2; Non-structural maintenance of chromosomes element 3 homolog; NSE3; NSMCE3
Gene Symbols: NSMCE3
Molecular weight: 34,308 Da
Basal Isoelectric point: 9.3  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB