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NSUN5
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 3782 in 28S rRNA. Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. Ubiquitous. Detected in placenta, heart and skeletal muscle. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.1.1.-; Methyltransferase; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 7q11.23 |
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Cellular Component:
nucleolus; nucleoplasm
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Molecular Function:
rRNA (cytosine-C5-)-methyltransferase activity
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Biological Process:
cerebral cortex development; cognition; corpus callosum development; oligodendrocyte development; positive regulation of translation; regulation of myelination; rRNA base methylation
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Reference #:
Q96P11
(UniProtKB)
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Alt. Names/Synonyms: 28S rRNA (cytosine-C(5))-methyltransferase; FLJ10267; MGC986; NOL1; NOL1-related protein; NOL1/NOP2/Sun domain family member 5; NOL1/NOP2/Sun domain family, member 5; NOL1R; NOP2/Sun domain family, member 5; NOP2/Sun domain family, member 5A; NOP2/Sun RNA methyltransferase 5; NOP2/Sun RNA methyltransferase family member 5; NSUN5; NSUN5A; p120; p120(NOL1); Probable 28S rRNA (cytosine-C(5))-methyltransferase; Putative methyltransferase NSUN5; WBSCR20; WBSCR20A; Williams Beuren syndrome chromosome region 20A; Williams-Beuren syndrome chromosomal region 20A protein; Williams-Beuren syndrome critical region protein 20 copy A
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Gene Symbols: NSUN5
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Molecular weight:
46,692 Da
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Basal Isoelectric point:
8.91
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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