EME1 Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks. Belongs to the EME1/MMS4 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Deoxyribonuclease; EC 3.1.22.-; Nucleolus
Chromosomal Location of Human Ortholog: 17q21.33
Cellular Component:  nuclear heterochromatin; nucleolus; nucleoplasm
Molecular Function:  DNA binding; metal ion binding; protein binding
Biological Process:  interstrand cross-link repair; nucleic acid phosphodiester bond hydrolysis; response to intra-S DNA damage checkpoint signaling
Reference #:  Q96AY2 (UniProtKB)
Alt. Names/Synonyms: Crossover junction endonuclease EME1; EME1; essential meiotic endonuclease 1 homolog 1; essential meiotic endonuclease 1 homolog 1 (S. pombe); essential meiotic endonuclease 1 homolog 2; essential meiotic structure-specific endonuclease 1; FLJ31364; hMMS4; homolog of yeast EME1 endonuclease; MMS4; MMS4 homolog; MMS4L; SLX2 structure-specific endonuclease subunit homolog A; SLX2A
Gene Symbols: EME1
Molecular weight: 63,252 Da
Basal Isoelectric point: 6.7  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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