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EME1
Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks. Belongs to the EME1/MMS4 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Deoxyribonuclease; EC 3.1.22.-; Nucleolus |
| Chromosomal Location of human Ortholog: 17q21.33 |
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Cellular Component:
endodeoxyribonuclease complex; heterochromatin; Holliday junction resolvase complex; nuclear replication fork; nucleolus; nucleoplasm
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Molecular Function:
crossover junction DNA endonuclease activity; DNA binding; metal ion binding; protein binding
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Biological Process:
double-strand break repair; mitotic intra-S DNA damage checkpoint signaling; replication fork processing; resolution of meiotic recombination intermediates; response to intra-S DNA damage checkpoint signaling
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Reference #:
Q96AY2
(UniProtKB)
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Alt. Names/Synonyms: Crossover junction endonuclease EME1; EME1; essential meiotic endonuclease 1 homolog 1; essential meiotic endonuclease 1 homolog 1 (S. pombe); essential meiotic endonuclease 1 homolog 2; essential meiotic structure-specific endonuclease 1; FLJ31364; hMMS4; homolog of yeast EME1 endonuclease; MMS4; MMS4 homolog; MMS4L; SLX2 structure-specific endonuclease subunit homolog A; SLX2A
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Gene Symbols: EME1
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Molecular weight:
63,252 Da
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Basal Isoelectric point:
6.7
Predict pI for various phosphorylation states
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