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SYN1 iso2
Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level. Belongs to the synapsin family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Vesicle |
| Chromosomal Location of human Ortholog: Xp11.3-p11.23 |
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Cellular Component:
anchored component of synaptic vesicle membrane; axon; cell junction; cytoskeleton; cytosol; dendrite; extrinsic component of synaptic vesicle membrane; Golgi apparatus; postsynaptic density; presynaptic active zone; Schaffer collateral - CA1 synapse; synaptic vesicle; synaptonemal complex
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Molecular Function:
actin binding; ATP binding; calcium-dependent protein binding; protein binding; protein kinase binding
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Biological Process:
chemical synaptic transmission; neuron development; regulation of neurotransmitter secretion; regulation of synaptic vesicle exocytosis; synapse organization; synaptic vesicle clustering
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Reference #:
P17600-2
(UniProtKB)
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Alt. Names/Synonyms: Brain protein 4.1; MRX50; SYN1; SYN1 iso2; SYN1a; SYN1b; Synapsin I; synapsin Ib; Synapsin-1; SYNI
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Gene Symbols: SYN1
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Molecular weight:
70,033 Da
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Basal Isoelectric point:
9.88
Predict pI for various phosphorylation states
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CST Pathways:
GPCR Signaling to MAPKs
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