UNC5D Receptor for the netrin NTN4 that promotes neuronal cell survival. Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration. Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. May play a role in apoptosis in response to DNA damage. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell. Belongs to the unc-5 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 8p12
Cellular Component:  cell surface; integral component of membrane; plasma membrane
Molecular Function:  netrin receptor activity
Biological Process:  apoptotic process; axon guidance; cell-cell adhesion via plasma-membrane adhesion molecules; netrin-activated signaling pathway; pyramidal neuron differentiation; regulation of neuron migration
Reference #:  Q6UXZ4 (UniProtKB)
Alt. Names/Synonyms: FLJ16019; KIAA1777; Netrin receptor UNC5D; netrin receptor Unc5h4; PRO34692; Protein unc-5 homolog 4; Protein unc-5 homolog D; unc-5 homolog 4; unc-5 homolog D; unc-5 homolog D (C. elegans); unc-5 netrin receptor D; UNC5D; UNC5H4
Gene Symbols: UNC5D
Molecular weight: 105,880 Da
Basal Isoelectric point: 5.71  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB