PAK1 a protein kinase of the STE20 family that regulates cell motility and morphology. Critical RhoGTPase effector that regulates cytoskeleton reorganization, the JNK MAPK pathway, and nuclear signaling. Binding of Rac/cdc42 to the PBD of PAK1 causes autophosphorylation and conformational change. Phosphorylated and activated by PDK. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; PAKA subfamily; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family
Chromosomal Location of Human Ortholog: 11q13.5-q14.1
Cellular Component:  axon; cytoplasm; cytosol; dendrite; filamentous actin; focal adhesion; intercalated disc; intercellular junction; invadopodium; lamellipodium; nuclear membrane; plasma membrane; ruffle; Z disc
Molecular Function:  ATP binding; collagen binding; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; Rac GTPase binding
Biological Process:  actin cytoskeleton organization; actin cytoskeleton reorganization; activation of protein kinase activity; apoptosis; branching morphogenesis of a tube; cell migration; cellular response to insulin stimulus; cerebellum development; ephrin receptor signaling pathway; establishment of cell polarity; exocytosis; Fc-epsilon receptor signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; hepatocyte growth factor receptor signaling pathway; MAPK cascade; neuron projection morphogenesis; positive regulation of axon extension; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of fibroblast migration; positive regulation of glucose import in response to insulin stimulus; positive regulation of intracellular estrogen receptor signaling pathway; positive regulation of JUN kinase activity; positive regulation of microtubule polymerization; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein phosphorylation; positive regulation of protein targeting to membrane; positive regulation of stress fiber formation; positive regulation of vascular associated smooth muscle cell migration; positive regulation of vascular smooth muscle cell proliferation; protein amino acid phosphorylation; protein autophosphorylation; regulation of axonogenesis; regulation of MAPK cascade; regulation of mitotic cell cycle; response to hypoxia; Rho protein signal transduction; stimulatory C-type lectin receptor signaling pathway; T cell costimulation; T cell receptor signaling pathway; wound healing
Disease: Intellectual Developmental Disorder With Macrocephaly, Seizures, And Speech Delay
Reference #:  Q13153 (UniProtKB)
Alt. Names/Synonyms: Alpha-PAK; MGC130000; MGC130001; p21 protein (Cdc42/Rac)-activated kinase 1; p21-activated kinase 1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast); p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related); p65-PAK; PAK-1; PAK1; PAKalpha; Serine/threonine-protein kinase PAK 1; STE20 homolog, yeast
Gene Symbols: PAK1
Molecular weight: 60,647 Da
Basal Isoelectric point: 5.55  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  Microtubule Dynamics  |  TGF-ß Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein