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SSH1
Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. Belongs to the protein-tyrosine phosphatase family. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.3.16; EC 3.1.3.48; Protein phosphatase, dual-specificity |
| Chromosomal Location of human Ortholog: 12q24.11 |
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Cellular Component:
cleavage furrow; cytoplasm; cytoskeleton; growth cone; lamellipodium; midbody; plasma membrane; synapse
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Molecular Function:
actin binding; myosin phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity
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Biological Process:
actin cytoskeleton organization; cell morphogenesis; cellular response to ATP; excitatory chemical synaptic transmission; negative regulation of actin filament polymerization; positive regulation of AMPA glutamate receptor clustering; positive regulation of excitatory postsynaptic potential; positive regulation of neuron death; positive regulation of synaptic plasticity; positive regulation of vascular associated smooth muscle cell migration; protein dephosphorylation; regulation of protein metabolic process
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Reference #:
Q8WYL5
(UniProtKB)
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Alt. Names/Synonyms: FLJ21928; FLJ38102; hSSH-1L; KIAA1298; Protein phosphatase Slingshot homolog 1; slingshot 1; slingshot homolog 1; slingshot homolog 1 (Drosophila); slingshot protein phosphatase 1; SSH-1L; SSH-like protein 1; SSH1; SSH1L
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Gene Symbols: SSH1
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Molecular weight:
115,511 Da
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Basal Isoelectric point:
5.87
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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