LEO1 Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling. Belongs to the LEO1 family. Highly expressed in skeletal muscle and heart. Weakly expressed in placenta and liver. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription regulation
Chromosomal Location of Human Ortholog: 15q21.2
Cellular Component:  Cdc73/Paf1 complex; centrosome; fibrillar center; nucleoplasm
Molecular Function:  protein binding
Biological Process:  beta-catenin-TCF complex assembly; endodermal cell fate commitment; histone H2B ubiquitination; histone monoubiquitination; mRNA polyadenylation; negative regulation of myeloid cell differentiation; positive regulation of mRNA 3'-end processing; positive regulation of transcription by RNA polymerase II; positive regulation of transcription elongation from RNA polymerase II promoter; protein ubiquitination; stem cell population maintenance; transcription by RNA polymerase II; transcription elongation from RNA polymerase II promoter; Wnt signaling pathway
Reference #:  Q8WVC0 (UniProtKB)
Alt. Names/Synonyms: LEO1; Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae); RDL; Replicative senescence down-regulated leo1-like protein; replicative senescence downregulated leo1-like; RNA polymerase-associated protein LEO1; senescence downregulated leo1-like
Gene Symbols: LEO1
Molecular weight: 75,404 Da
Basal Isoelectric point: 4.38  Predict pI for various phosphorylation states
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LEO1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB