SNX33 Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes. Belongs to the sorting nexin family. Detected in heart and pancreas. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 15q24.2
Cellular Component:  cytoplasmic vesicle; cytoplasmic vesicle membrane; cytosol; extrinsic component of membrane; membrane
Molecular Function:  identical protein binding; phosphatidylinositol binding; protein binding
Biological Process:  cleavage furrow formation; endocytosis; endosomal transport; endosome organization; intracellular protein transport; macropinocytosis; mitotic cytokinesis; negative regulation of endocytosis; negative regulation of protein localization to cell surface; plasma membrane tubulation; positive regulation of membrane protein ectodomain proteolysis; positive regulation of protein localization to cell surface; protein import
Reference #:  Q8WV41 (UniProtKB)
Alt. Names/Synonyms: MGC32065; SH3 and PX domain containing 3; SH3 and PX domain-containing protein 3; SH3PX3; SH3PXD3C; SNX30; SNX33; sorting nexin 33; Sorting nexin-33
Gene Symbols: SNX33
Molecular weight: 65,265 Da
Basal Isoelectric point: 6.3  Predict pI for various phosphorylation states
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SNX33

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene