DEM1 Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3'-5' exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'-directionality activity. Belongs to the EXO5 family. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.11.-
Chromosomal Location of Human Ortholog: 1p34.2
Cellular Component:  cytosol; nucleoplasm; nucleus
Molecular Function:  4 iron, 4 sulfur cluster binding; DNA binding; metal ion binding; protein homodimerization activity; single-stranded DNA 3'-5' exodeoxyribonuclease activity; single-stranded DNA 5'-3' exodeoxyribonuclease activity
Biological Process:  interstrand cross-link repair; nucleic acid phosphodiester bond hydrolysis
Reference #:  Q9H790 (UniProtKB)
Alt. Names/Synonyms: C1orf176; defects in morphology 1 homolog; Defects in morphology protein 1 homolog; DEM1; Exo V; EXO5; exonuclease 5; Exonuclease V; FLJ11445; FLJ13183; FLJ21144; hExo5
Gene Symbols: EXO5
Molecular weight: 41,816 Da
Basal Isoelectric point: 5.28  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene