WIRE Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system. Belongs to the verprolin family. Expressed mainly in brain, colon, lung and stomach (at protein level). Ubiquitously expressed, with high expression in brain, kidney, lung, and placenta. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 17q21.2
Cellular Component:  cytosol; nucleoplasm; plasma membrane
Molecular Function:  protein binding
Biological Process:  Fc-gamma receptor signaling pathway involved in phagocytosis
Reference #:  Q8TF74 (UniProtKB)
Alt. Names/Synonyms: WAS/WASL interacting protein family member 2; WAS/WASL interacting protein family, member 2; WAS/WASL-interacting protein family member 2; WASP-binding protein; WASP-interacting protein-related protein; WICH; WIP- and CR16-homologous protein; WIP-related protein; WIPF2; WIRE
Gene Symbols: WIPF2
Molecular weight: 46,289 Da
Basal Isoelectric point: 10.93  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene