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WIRE
Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system. Belongs to the verprolin family. Expressed mainly in brain, colon, lung and stomach (at protein level). Ubiquitously expressed, with high expression in brain, kidney, lung, and placenta. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of Human Ortholog: 17q21.2 |
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Cellular Component:
cytosol; nucleoplasm; plasma membrane
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Molecular Function:
protein binding
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Biological Process:
Fc-gamma receptor signaling pathway involved in phagocytosis
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Reference #:
Q8TF74
(UniProtKB)
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Alt. Names/Synonyms: WAS/WASL interacting protein family member 2; WAS/WASL interacting protein family, member 2; WAS/WASL-interacting protein family member 2; WASP-binding protein; WASP-interacting protein-related protein; WICH; WIP- and CR16-homologous protein; WIP-related protein; WIPF2; WIRE
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Gene Symbols: WIPF2
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Molecular weight:
46,289 Da
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Basal Isoelectric point:
10.93
Predict pI for various phosphorylation states
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