SCC-112 Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Belongs to the PDS5 family. Highest level in colon. Low levels in lung, ovary, breast and kidney. Reduced level in renal tumor tissue. Isoform 2 is expressed in kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 4p14
Cellular Component:  chromatin; chromosome; chromosome, centromeric region; cytosol; nucleoplasm; plasma membrane
Molecular Function:  protein binding
Biological Process:  cell division; mitotic sister chromatid cohesion; negative regulation of DNA replication
Reference #:  Q29RF7 (UniProtKB)
Alt. Names/Synonyms: Cell proliferation-inducing gene 54 protein; cell proliferation-inducing protein 54; DKFZp686B19246; FLJ41012; KIAA0648; MGC131948; MGC161503; PDS5; PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae); PDS5A; PIG54; SCC-112; Sister chromatid cohesion protein 112; Sister chromatid cohesion protein PDS5 homolog A
Gene Symbols: PDS5A
Molecular weight: 150,830 Da
Basal Isoelectric point: 8.15  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein