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SLC5A1
Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. Expressed mainly in intestine and kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family |
| Chromosomal Location of human Ortholog: 22q12.3 |
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Cellular Component:
apical plasma membrane; brush border membrane; early endosome; intracellular organelle; intracellular vesicle; membrane; perinuclear region of cytoplasm; plasma membrane
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Molecular Function:
alpha-glucoside transmembrane transporter activity; D-glucose transmembrane transporter activity; fucose transmembrane transporter activity; galactose transmembrane transporter activity; galactose:sodium symporter activity; glucose transmembrane transporter activity; glucose:sodium symporter activity; myo-inositol:sodium symporter activity; pentose transmembrane transporter activity; protein binding; water transmembrane transporter activity
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Biological Process:
alpha-glucoside transport; chloride transmembrane transport; fucose transmembrane transport; galactose transmembrane transport; glucose import across plasma membrane; glucose transmembrane transport; intestinal D-glucose absorption; intestinal hexose absorption; myo-inositol transport; pentose transmembrane transport; renal glucose absorption; response to inorganic substance; sodium ion import across plasma membrane; sodium ion transport; transepithelial water transport; transport across blood-brain barrier
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Disease: Glucose/galactose Malabsorption
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Reference #:
P13866
(UniProtKB)
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Alt. Names/Synonyms: D22S675; High affinity sodium-glucose cotransporter; Na(+)/glucose cotransporter 1; Na+/glucose cotransporter 1; NAGT; SC5A1; SGLT1; SLC5A1; Sodium/glucose cotransporter 1; solute carrier family 5 (sodium/glucose cotransporter), member 1; Solute carrier family 5 member 1; solute carrier family 5, member 1
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Gene Symbols: SLC5A1
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Molecular weight:
73,498 Da
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Basal Isoelectric point:
7.82
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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