SLC5A1 Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. Expressed mainly in intestine and kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of human Ortholog: 22q12.3
Cellular Component:  apical plasma membrane; brush border membrane; early endosome; intracellular organelle; intracellular vesicle; membrane; perinuclear region of cytoplasm; plasma membrane
Molecular Function:  alpha-glucoside transmembrane transporter activity; D-glucose transmembrane transporter activity; fucose transmembrane transporter activity; galactose transmembrane transporter activity; galactose:sodium symporter activity; glucose transmembrane transporter activity; glucose:sodium symporter activity; myo-inositol:sodium symporter activity; pentose transmembrane transporter activity; protein binding; water transmembrane transporter activity
Biological Process:  alpha-glucoside transport; chloride transmembrane transport; fucose transmembrane transport; galactose transmembrane transport; glucose import across plasma membrane; glucose transmembrane transport; intestinal D-glucose absorption; intestinal hexose absorption; myo-inositol transport; pentose transmembrane transport; renal glucose absorption; response to inorganic substance; sodium ion import across plasma membrane; sodium ion transport; transepithelial water transport; transport across blood-brain barrier
Disease: Glucose/galactose Malabsorption
Reference #:  P13866 (UniProtKB)
Alt. Names/Synonyms: D22S675; High affinity sodium-glucose cotransporter; Na(+)/glucose cotransporter 1; Na+/glucose cotransporter 1; NAGT; SC5A1; SGLT1; SLC5A1; Sodium/glucose cotransporter 1; solute carrier family 5 (sodium/glucose cotransporter), member 1; Solute carrier family 5 member 1; solute carrier family 5, member 1
Gene Symbols: SLC5A1
Molecular weight: 73,498 Da
Basal Isoelectric point: 7.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB