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PARD6G
Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Belongs to the PAR6 family. Widely expressed, with a higher expression in fetal and adult kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Cell adhesion; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 18q23 |
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Cellular Component:
apical plasma membrane; bicellular tight junction; cell cortex; cytosol; nucleus; PAR polarity complex; plasma membrane; tight junction
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Molecular Function:
protein binding; protein kinase C binding
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Biological Process:
cell division; centrosome cycle; establishment or maintenance of cell polarity; establishment or maintenance of epithelial cell apical/basal polarity; regulation of cellular localization
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Reference #:
Q9BYG4
(UniProtKB)
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Alt. Names/Synonyms: FLJ45701; par-6 family cell polarity regulator gamma; PAR-6 gamma; PAR-6 gamma protein; par-6 partitioning defective 6 homolog gamma; par-6 partitioning defective 6 homolog gamma (C. elegans); PAR-6G; PAR6D; PAR6G; PAR6gamma; PARD6G; Partitioning defective 6 homolog gamma
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Gene Symbols: PARD6G
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Molecular weight:
40,883 Da
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Basal Isoelectric point:
8.36
Predict pI for various phosphorylation states
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CST Pathways:
Adherens Junction Dynamics
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Microtubule Dynamics
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TGF-ß Signaling
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