PARD6G Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Belongs to the PAR6 family. Widely expressed, with a higher expression in fetal and adult kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Cell adhesion; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 18q23
Cellular Component:  apical plasma membrane; bicellular tight junction; cell cortex; cytosol; nucleus; PAR polarity complex; plasma membrane; tight junction
Molecular Function:  protein binding; protein kinase C binding
Biological Process:  cell division; centrosome cycle; establishment or maintenance of cell polarity; establishment or maintenance of epithelial cell apical/basal polarity; regulation of cellular localization
Reference #:  Q9BYG4 (UniProtKB)
Alt. Names/Synonyms: FLJ45701; par-6 family cell polarity regulator gamma; PAR-6 gamma; PAR-6 gamma protein; par-6 partitioning defective 6 homolog gamma; par-6 partitioning defective 6 homolog gamma (C. elegans); PAR-6G; PAR6D; PAR6G; PAR6gamma; PARD6G; Partitioning defective 6 homolog gamma
Gene Symbols: PARD6G
Molecular weight: 40,883 Da
Basal Isoelectric point: 8.36  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Microtubule Dynamics  |  TGF-ß Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB