RBM15B RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex. Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist. Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation. Inhibits pre-mRNA splicing. Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1. Belongs to the RRM Spen family. Ubiquitously expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA-binding
Chromosomal Location of human Ortholog: 3p21.2
Cellular Component:  nuclear envelope; nuclear speck; nucleolus; nucleoplasm; nucleus; RNA N6-methyladenosine methyltransferase complex
Molecular Function:  mRNA binding; protein binding; RNA binding
Biological Process:  dosage compensation by inactivation of X chromosome; mRNA export from nucleus; mRNA processing; negative regulation of DNA-templated transcription; nucleocytoplasmic transport; regulation of alternative mRNA splicing, via spliceosome; RNA methylation; RNA splicing
Reference #:  Q8NDT2 (UniProtKB)
Alt. Names/Synonyms: chromosome 3p21.1 gene sequence; HsOTT3; HUMAGCGB; HuOTT3; one twenty two protein 3; One-twenty two protein 3; OTT3; Putative RNA-binding protein 15B; RB15B; RBM15B; RNA binding motif protein 15B; RNA-binding motif protein 15B
Gene Symbols: RBM15B
Molecular weight: 97,205 Da
Basal Isoelectric point: 9.86  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein