EHBP1 May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking. Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Vesicle
Chromosomal Location of human Ortholog: 2p15
Cellular Component:  cytosol; endosome; nucleoplasm; plasma membrane
Biological Process:  endocytosis; protein transport
Disease: Prostate Cancer, Hereditary, 12
Reference #:  Q8NDI1 (UniProtKB)
Alt. Names/Synonyms: EH domain binding protein 1; EH domain-binding protein 1; EHBP1; HPC12; KIAA0903; NACSIN; NPF calponin-like protein; testis tissue sperm-binding protein Li 50e
Gene Symbols: EHBP1
Molecular weight: 140,017 Da
Basal Isoelectric point: 5.24  Predict pI for various phosphorylation states
CST Pathways:  Insulin Receptor Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein