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CBCP1
Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription. Belongs to the cyclin family. Cyclin Y subfamily. Widely expressed. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell cycle regulation |
| Chromosomal Location of Human Ortholog: 10p11.21 |
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Cellular Component:
cytoplasmic cyclin-dependent protein kinase holoenzyme complex; nucleus; plasma membrane
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Molecular Function:
cyclin-dependent protein serine/threonine kinase regulator activity; protein binding; protein kinase binding
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Biological Process:
cell division; G2/M transition of mitotic cell cycle; positive regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of canonical Wnt signaling pathway; Wnt signaling pathway
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Reference #:
Q8ND76
(UniProtKB)
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Alt. Names/Synonyms: C10orf9; CBCP1; CCNX; CCNY; CFP1; Cyc-Y; Cyclin box protein 1; Cyclin fold protein 1; cyclin Y; cyclin-box carrying protein 1; cyclin-X; Cyclin-Y; FLJ95513
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Gene Symbols: CCNY
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Molecular weight:
39,337 Da
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Basal Isoelectric point:
6.76
Predict pI for various phosphorylation states
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