RNF169 Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. Belongs to the RNF169 family. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 11q13.4
Cellular Component:  nuclear speck; nucleoplasm; nucleus; site of double-strand break
Molecular Function:  K63-linked polyubiquitin modification-dependent protein binding; metal ion binding; nucleosome binding; transferase activity
Biological Process:  cellular response to DNA damage stimulus; negative regulation of double-strand break repair; protein ubiquitination
Reference #:  Q8NCN4 (UniProtKB)
Alt. Names/Synonyms: E3 ubiquitin-protein ligase RNF169; KIAA1991; RING finger protein 169; RN169; RNF169
Gene Symbols: RNF169
Molecular weight: 77,194 Da
Basal Isoelectric point: 9.28  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene