PICH DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Functions as ATP-dependent DNA translocase. Can promote Holliday junction branch migration (in vitro). Belongs to the SNF2/RAD54 helicase family. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.4.12; Helicase
Chromosomal Location of human Ortholog: Xq13.1
Cellular Component:  condensed chromosome kinetochore; cytosol
Molecular Function:  ATP binding; DNA binding; DNA translocase activity; helicase activity; protein binding
Biological Process:  cell cycle; cell division
Reference #:  Q2NKX8 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent helicase ERCC6-like; DNA excision repair protein ERCC-6-like; ERC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase; ERCC6L; excision repair cross-complementation group 6 like; excision repair cross-complementing rodent repair deficiency complementation group 6 - like; excision repair cross-complementing rodent repair deficiency, complementation group 6-like; excision repair protein ERCC6-like; FLJ20105; MGC131695; PICH; PLK1-interacting checkpoint helicase; RAD26L; SNF2/RAD54 family protein; Tumor antigen BJ-HCC-15
Gene Symbols: ERCC6L
Molecular weight: 141,103 Da
Basal Isoelectric point: 5.19  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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PICH

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene