HJURP Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions. According to PubMed:17256767, highly expressed in the thymus with lower levels in the placenta, small intestine, liver, skeletal muscle, and colon. According to PubMed:17823411, highly expressed in testis, and at a relatively lower level in thymus and bone marrow. Significantly overexpressed in many lung cancer samples, compared with normal lung. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Histone-binding; Nucleolus
Chromosomal Location of Human Ortholog: 2q37.1
Cellular Component:  chromosome, centromeric region; condensed chromosome kinetochore; cytosol; mitochondrion; nucleolus; nucleoplasm; nucleus
Molecular Function:  DNA binding; histone binding; identical protein binding; protein binding
Biological Process:  cell cycle; CENP-A containing nucleosome assembly; chromosome segregation; regulation of DNA binding; regulation of protein complex assembly
Reference #:  Q8NCD3 (UniProtKB)
Alt. Names/Synonyms: 14-3-3-associated AKT substrate; DKFZp762E1312; FAKTS; fetal liver expressing gene 1; Fetal liver-expressing gene 1 protein; FLEG1; hFLEG1; HJURP; Holliday junction recognition protein; Up-regulated in lung cancer 9; URLC9
Gene Symbols: HJURP
Molecular weight: 83,539 Da
Basal Isoelectric point: 9.4  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene