ATAD2 May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. Belongs to the AAA ATPase family. Highly expressed in estrogen receptor positive breast tumors and in osteosarcoma tumors. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cancer Testis Antigen (CTA); EC 3.6.1.3; Hydrolase
Chromosomal Location of Human Ortholog: 8q24.13
Cellular Component:  nucleoplasm
Molecular Function:  ATP binding; ATPase activity; protein binding
Biological Process:  chromatin organization; positive regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II
Reference #:  Q6PL18 (UniProtKB)
Alt. Names/Synonyms: AAA nuclear coregulator cancer-associated protein; ANCCA; ATAD2; ATPase family AAA domain containing 2; ATPase family AAA domain-containing protein 2; ATPase family, AAA domain containing 2; CT137; DKFZp667N1320; MGC131938; MGC142216; MGC29843; MGC5254; PRO2000
Gene Symbols: ATAD2
Molecular weight: 158,554 Da
Basal Isoelectric point: 5.94  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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ATAD2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene