AFAP Can cross-link actin filaments into both network and bundle structures. May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells. Low expression in normal breast epithelial cell line MCF-10A and in tumorigenic breast cancer cell lines MCF-7, T-47D and ZR-75-1. Highly expressed in the invasive breast cancer cell lines MDA-MB-231 and MDA-MB-435. Overexpressed in prostate carcinoma. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of human Ortholog: 4p16.1
Cellular Component:  actin cytoskeleton; cytosol; focal adhesion
Molecular Function:  actin binding
Biological Process:  regulation of cytoskeleton organization; regulation of signal transduction
Reference #:  Q8N556 (UniProtKB)
Alt. Names/Synonyms: 110 kDa actin filament-associated protein; actin filament associated protein 1; Actin filament-associated protein 1; actin filament-associated protein, 110 kDa; AFAP; AFAP-110; AFAP1; AFAP110; FLJ56849
Gene Symbols: AFAP1
Molecular weight: 80,725 Da
Basal Isoelectric point: 8.87  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein