AFAP
Can cross-link actin filaments into both network and bundle structures. May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells. Low expression in normal breast epithelial cell line MCF-10A and in tumorigenic breast cancer cell lines MCF-7, T-47D and ZR-75-1. Highly expressed in the invasive breast cancer cell lines MDA-MB-231 and MDA-MB-435. Overexpressed in prostate carcinoma. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Adaptor/scaffold |
Chromosomal Location of human Ortholog: 4p16.1 |
Cellular Component:
actin cytoskeleton; cytosol; focal adhesion
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Molecular Function:
actin binding; SH2 domain binding; SH3 domain binding
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Reference #:
Q8N556
(UniProtKB)
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Alt. Names/Synonyms: 110 kDa actin filament-associated protein; actin filament associated protein 1; Actin filament-associated protein 1; actin filament-associated protein, 110 kDa; AFAP; AFAP-110; AFAP1; AFAP110; FLJ56849
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Gene Symbols: AFAP1
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Molecular weight:
80,725 Da
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Basal Isoelectric point:
8.87
Predict pI for various phosphorylation states
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