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LIMCH1 iso3
Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. Belongs to the LIMCH1 family. 10 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Actin-binding |
| Chromosomal Location of human Ortholog: 4p13 |
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Cellular Component:
cytoplasm; stress fiber
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Molecular Function:
actin binding; metal ion binding; myosin II head/neck binding
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Biological Process:
actomyosin structure organization; cytoplasmic actin-based contraction involved in cell motility; negative regulation of cell migration; positive regulation of protein phosphorylation; positive regulation of stress fiber assembly; regulation of focal adhesion assembly
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Reference #:
Q9UPQ0-3
(UniProtKB)
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Alt. Names/Synonyms: DKFZp434I0312; DKFZp686A01247; DKFZp686B2470; DKFZp686G18243; DKFZp686G2094; DKFZp781C1754; DKFZp781I1455; KIAA1102; LIM and calponin homology domains 1; LIM and calponin homology domains-containing protein 1; LIMC1; LIMCH1; LIMCH1 iso3; LIMCH1A; LMO7B; MGC72127
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Gene Symbols: LIMCH1
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Molecular weight:
164,440 Da
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Basal Isoelectric point:
5.93
Predict pI for various phosphorylation states
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