LIMCH1 iso3 Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. Belongs to the LIMCH1 family. 10 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding
Chromosomal Location of Human Ortholog: 4p13
Cellular Component:  cytoplasm; stress fiber
Molecular Function:  actin binding; metal ion binding; myosin II head/neck binding
Biological Process:  actomyosin structure organization; negative regulation of cell migration; positive regulation of protein phosphorylation; positive regulation of stress fiber assembly; regulation of focal adhesion assembly
Reference #:  Q9UPQ0-3 (UniProtKB)
Alt. Names/Synonyms: DKFZp434I0312; DKFZp686A01247; DKFZp686B2470; DKFZp686G18243; DKFZp686G2094; DKFZp781C1754; DKFZp781I1455; KIAA1102; LIM and calponin homology domains 1; LIM and calponin homology domains-containing protein 1; LIMC1; LIMCH1; LIMCH1 iso3; LIMCH1A; LMO7B; MGC72127
Gene Symbols: LIMCH1
Molecular weight: 164,440 Da
Basal Isoelectric point: 5.93  Predict pI for various phosphorylation states
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LIMCH1 iso3

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  InnateDB