BPY2-IP1
Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles. Belongs to the MAP1 family. Expressed in neurons (at protein level). Expressed in spermatocytes, spermatids and spermatozoa. Expressed in the cerebral cortex. Highly expressed in testis. Moderately expressed in the brain, colon, heart, kidney, liver, lung, placenta, small intestine, spleen and stomach. Weakly expressed in muscle. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Apoptosis; Microtubule-binding |
Chromosomal Location of human Ortholog: 19p13.11 |
Cellular Component:
cell junction; cell projection; centrosome; cytosol; dendrite; microtubule; microtubule associated complex; microtubule organizing center; mitotic spindle microtubule; neuronal cell body; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm; spindle; synapse
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Molecular Function:
actin binding; actin filament binding; beta-tubulin binding; DNA binding; DNA nuclease activity; identical protein binding; microtubule binding; protein binding; tubulin binding
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Biological Process:
apoptotic process; autophagy; axonogenesis; brain development; dendrite development; metaphase plate congression; microtubule anchoring at centrosome; microtubule bundle formation; microtubule cytoskeleton organization; mitochondrion transport along microtubule; mitotic spindle organization; nervous system development; neuron projection morphogenesis; regulation of microtubule depolymerization
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Reference #:
Q66K74
(UniProtKB)
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Alt. Names/Synonyms: BPY2 interacting protein 1; BPY2-interacting protein 1; BPY2-IP1; BPY2IP1; C19orf5; FLJ10669; MAP-1S; MAP1S; MAP1S heavy chain; MAP1S light chain; MAP8; MGC133087; microtubule associated protein 1S; Microtubule-associated protein 1S; Microtubule-associated protein 8; Variable charge Y chromosome 2-interacting protein 1; VCY2 interacting protein 1; VCY2-interacting protein 1; VCY2IP-1; VCY2IP1
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Gene Symbols: MAP1S
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Molecular weight:
112,211 Da
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Basal Isoelectric point:
6.93
Predict pI for various phosphorylation states
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