INTS1 Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. Belongs to the Integrator subunit 1 family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; RNA processing
Chromosomal Location of Human Ortholog: 7p22.3
Cellular Component:  integral component of membrane; integrator complex; nuclear membrane; nucleoplasm
Biological Process:  snRNA processing; snRNA transcription by RNA polymerase II
Disease: Neurodevelopmental Disorder With Cataracts, Poor Growth, And Dysmorphic Facies
Reference #:  Q8N201 (UniProtKB)
Alt. Names/Synonyms: DKFZp586J0619; FLJ46624; Int1; Integrator complex subunit 1; INTS1; KIAA1440; NDCAGF; NET28
Gene Symbols: INTS1
Molecular weight: 244,297 Da
Basal Isoelectric point: 5.77  Predict pI for various phosphorylation states
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INTS1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB