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Raptor
Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Involved in ciliogenesis. Belongs to the WD repeat RAPTOR family. Highly expressed in skeletal muscle, and in a lesser extent in brain, lung, small intestine, kidney and placenta. Isoform 3 is widely expressed, with highest levels in nasal mucosa and pituitary and lowest in spleen. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of human Ortholog: 17q25.3 |
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Cellular Component:
cytoplasm; cytoplasmic stress granule; cytosol; dendrite; lysosome; neuronal cell body; nucleoplasm; TORC1 complex
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Molecular Function:
14-3-3 protein binding; protein binding; protein kinase activator activity; protein kinase binding; protein serine/threonine kinase inhibitor activity; protein-containing complex binding; protein-macromolecule adaptor activity; RNA polymerase III type 1 promoter sequence-specific DNA binding; RNA polymerase III type 2 promoter sequence-specific DNA binding; RNA polymerase III type 3 promoter sequence-specific DNA binding; TFIIIC-class transcription factor complex binding
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Biological Process:
cellular response to amino acid stimulus; cellular response to hypoxia; cellular response to leucine; cellular response to nutrient levels; cellular response to osmotic stress; cellular response to starvation; DNA damage response; negative regulation of autophagy; phosphorylation; positive regulation of cell growth; positive regulation of endothelial cell proliferation; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of glycolytic process; positive regulation of lipid biosynthetic process; positive regulation of pentose-phosphate shunt; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-threonine phosphorylation; positive regulation of protein serine/threonine kinase activity; positive regulation of TOR signaling; positive regulation of transcription by RNA polymerase III; regulation of autophagy; regulation of cell growth; regulation of cell size; response to xenobiotic stimulus; social behavior; TOR signaling; TORC1 signaling
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Reference #:
Q8N122
(UniProtKB)
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Alt. Names/Synonyms: KIAA1303; KOG1; Mip1; p150 target of rapamycin (TOR)-scaffold protein; p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats; RAPTOR; regulatory associated protein of MTOR complex 1; regulatory associated protein of MTOR, complex 1; Regulatory-associated protein of mTOR; RPTOR
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Gene Symbols: RPTOR
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Molecular weight:
149,038 Da
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Basal Isoelectric point:
6.43
Predict pI for various phosphorylation states
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CST Pathways:
AMPK Signaling
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Autophagy Signaling
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Insulin Receptor Signaling
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mTOR Signaling
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PI3K/Akt Signaling
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T Cell Receptor Signaling
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Translation: eIF4E and p70S6K
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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