ELYS Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. Belongs to the ELYS family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of human Ortholog: 1q44
Cellular Component:  chromatin; cytosol; kinetochore; nuclear envelope; nuclear matrix; nuclear membrane; nuclear pore; nucleoplasm; nucleus
Molecular Function:  DNA binding
Biological Process:  cell cycle; cell division; mRNA transport; nuclear pore complex assembly; nucleocytoplasmic transport; protein transport; regulation of cytokinesis
Reference #:  Q8WYP5 (UniProtKB)
Alt. Names/Synonyms: AHCTF1; AT hook containing transcription factor 1; AT-hook containing transcription factor 1; DKFZp434N093; ELYS; ELYS transcription factor like protein TMBS62; ELYS transcription factor-like protein TMBS62; Embryonic large molecule derived from yolk sac; MST108; MSTP108; Protein ELYS; Protein MEL-28; Putative AT-hook-containing transcription factor 1; TMBS62
Gene Symbols: AHCTF1
Molecular weight: 252,498 Da
Basal Isoelectric point: 6.19  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene