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ELYS
Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis. Belongs to the ELYS family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Transcription factor |
| Chromosomal Location of human Ortholog: 1q44 |
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Cellular Component:
chromatin; cytosol; kinetochore; nuclear envelope; nuclear matrix; nuclear membrane; nuclear pore; nucleoplasm; nucleus
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Molecular Function:
DNA binding
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Biological Process:
cell cycle; cell division; mRNA transport; nuclear pore complex assembly; nucleocytoplasmic transport; protein transport; regulation of cytokinesis
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Reference #:
Q8WYP5
(UniProtKB)
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Alt. Names/Synonyms: AHCTF1; AT hook containing transcription factor 1; AT-hook containing transcription factor 1; DKFZp434N093; ELYS; ELYS transcription factor like protein TMBS62; ELYS transcription factor-like protein TMBS62; Embryonic large molecule derived from yolk sac; MST108; MSTP108; Protein ELYS; Protein MEL-28; Putative AT-hook-containing transcription factor 1; TMBS62
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Gene Symbols: AHCTF1
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Molecular weight:
252,498 Da
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Basal Isoelectric point:
6.19
Predict pI for various phosphorylation states
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