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NTE
Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Belongs to the NTE family. Expressed in brain, placenta, kidney, neuron and skeletal muscle. Expressed in the developing eye, pituitary and brain. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.1.5; Hydrolase; Membrane protein, integral |
| Chromosomal Location of human Ortholog: 19p13.2 |
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Cellular Component:
cytosol; endoplasmic reticulum; endoplasmic reticulum membrane
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Molecular Function:
lysophospholipase activity; phosphatidyl phospholipase B activity
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Biological Process:
glycerophospholipid catabolic process; phosphatidylcholine metabolic process
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Disease: Boucher-neuhauser Syndrome; Laurence-moon Syndrome; Oliver-mcfarlane Syndrome; Spastic Paraplegia 39, Autosomal Recessive
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Reference #:
Q8IY17
(UniProtKB)
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Alt. Names/Synonyms: BNHS; iPLA2delta; LNMS; Neuropathy target esterase; NTE; NTEMND; OMCS; patatin like phospholipase domain containing 6; patatin-like phospholipase domain containing 6; Patatin-like phospholipase domain-containing protein 6; PLPL6; PNPLA6; SPG39; sws
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Gene Symbols: PNPLA6
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Molecular weight:
150,954 Da
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Basal Isoelectric point:
7.89
Predict pI for various phosphorylation states
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